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(+)-Isocorynoline
| Product Name | (+)-Isocorynoline |
| Price: | $82 / 20mg |
| Catalog No.: | CN01398 |
| CAS No.: | 475-67-2 |
| Molecular Formula: | C20H23NO4 |
| Molecular Weight: | 341.40 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Cryst. |
| Source: | The tubers of Corydalis ambigua |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc2c(c1O)c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3 |
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| Description | Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC)[1]. |
| In Vitro | Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387[1]. Isocorydine (0-400 ug/ml; 48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines[1]. Cell Viability Assay[1] Cell Line: Huh-7, Hep-G2 , SNU-387, SNU-449 cells Concentration: 0-400 ug/ml Incubation Time: 24 hours Result: Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone. Western Blot Analysis[1] Cell Line: Huh-7, Hep-G2 , SNU-387, SNU-449 cells Concentration: Incubation Time: 24 hours Result: Downregulated protein levels of Claundin-1 and E-cadherin. |
| In Vivo | Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth[1]. Animal Model: Female nude mice[1] Dosage: 0.4 mg/ml Administration: Injected intraperitoneally every 2 days for 2 weeks Result: Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 506.1±50.0 °C at 760 mmHg |
| Flash Point | 259.9±30.1 °C |
| Exact Mass | 341.162720 |
| PSA | 51.16000 |
| LogP | 3.09 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Storage condition | -20℃ |