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MK-0752
| Product Name | MK-0752 |
| Price: | Inquiry |
| Catalog No.: | CN00112 |
| CAS No.: | 471905-41-6 |
| Molecular Formula: | C21H21ClF2O4S |
| Molecular Weight: | 442.9 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)CC[C@@H]1CC[C@](CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(cc1)Cl |
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| Description | MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.IC50 value: 5 nM (reduces Aβ40 production) [1]Target: γ-secretasein vitro: MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells [1]. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation [2]. in vivo: MK-0752 (240 mg/kg) reduces the generation of newly produced Aβ with 90% decrease of AUV in the brain of rhesus monkeys. In addition, MK-0752 treatment increases levels of Aβ 1-14, Aβ 1-15, and Aβ 1-16 , while decreases levels of Aβ 1-17 [1]. In guinea-pigs, oral administration of MK-0752 (10 mg/kg -30 mg/kg) results in the dose-dependent reduction of Aβ40 in plasma, brain and cerebrospinal fluid (CSF) with IC50 of 440 nM in brain [2]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 616.9±55.0 °C at 760 mmHg |
| Flash Point | 326.9±31.5 °C |
| Exact Mass | 442.081726 |
| PSA | 79.82000 |
| LogP | 4.41 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Storage condition | -20℃ |