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Cinobufagin
| Product Name | Cinobufagin |
| Price: | $92 / 20mg |
| Catalog No.: | CN02536 |
| CAS No.: | 470-37-1 |
| Molecular Formula: | C26H34O6 |
| Molecular Weight: | 442.55 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The glandular body of Bufo bufo gargarizans Cantor |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer.IC50 value:Target:In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2].In vivo: |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 595.4±50.0 °C at 760 mmHg |
| Flash Point | 199.4±23.6 °C |
| Exact Mass | 442.235535 |
| PSA | 89.27000 |
| LogP | 2.43 |
| Vapour Pressure | 0.0±3.8 mmHg at 25°C |
| Storage condition | 2-8°C |