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Cafestol
| Product Name | Cafestol |
| Price: | $146 / 20mg |
| Catalog No.: | CN08248 |
| CAS No.: | 469-83-0 |
| Molecular Formula: | C20H28O3 |
| Molecular Weight: | 316.44 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | From Coffea Bean |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OCC1(O)CC23CC1CCC3C1(C(CC2)c2ccoc2CC1)C |
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| Description | Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1]. |
| Target | ERK COX-2 NF-κB |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 468.6±45.0 °C at 760 mmHg |
| Flash Point | 237.2±28.7 °C |
| Exact Mass | 316.203857 |
| PSA | 53.60000 |
| LogP | 4.03 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |