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Jervine
| Product Name | Jervine |
| Price: | $46 / 20mg |
| Catalog No.: | CN01024 |
| CAS No.: | 469-59-0 |
| Molecular Formula: | C27H39NO3 |
| Molecular Weight: | 425.6 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Veratrum nigrum L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2C(=O)C2=C(C)[C@]4(CC[C@@H]32)O[C@H]2[C@H]([C@H]4C)NC[C@H](C2)C)C1)C |
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| Description | Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.IC50 value:Target: sonic hedgehog is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 592.0±50.0 °C at 760 mmHg |
| Flash Point | 311.8±30.1 °C |
| Exact Mass | 425.292999 |
| PSA | 58.56000 |
| LogP | 3.46 |
| Vapour Pressure | 0.0±3.8 mmHg at 25°C |