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Nootkatone
| Product Name | Nootkatone |
| Price: | $15 / 20mg |
| Catalog No.: | CN09428 |
| CAS No.: | 4674-50-4 |
| Molecular Formula: | C15H22O |
| Molecular Weight: | 218.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Oil |
| Source: | The rhizoma of Bupleurum longibrachiatum Turcz. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C1C[C@@H](C)[C@]2(C(=C1)CC[C@H](C2)C(=C)C)C |
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| Description | Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2]. |
| In Vivo | Nootkatone (10 mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10 mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10 mg/kg) decreased the high expression of these inflammatory cytokines[1]. |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 318.6±42.0 °C at 760 mmHg |
| Flash Point | 142.1±18.7 °C |
| Exact Mass | 218.167068 |
| PSA | 17.07000 |
| LogP | 3.84 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Storage condition | 2-8°C |