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Hecogenin
| Product Name | Hecogenin |
| Price: | $131 / 20mg |
| Catalog No.: | CN02530 |
| CAS No.: | 467-55-0 |
| Molecular Formula: | C27H42O4 |
| Molecular Weight: | 430.62 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The roots of Aconitum carmichaeli Debx |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C[C@@H]1CC[C@@]2(OC1)O[C@@H]1[C@H]([C@@H]2C)[C@@]2([C@@H](C1)[C@@H]1CC[C@@H]3[C@]([C@H]1CC2=O)(C)CC[C@@H](C3)O)C |
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| Description | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. |
| Target | Human UDP-glucuronosyltransferases[1] |
| In Vivo | Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1]. Animal Model: Male Swiss mice (20-30 g) with ethanol[1] Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration: Oral administration; for 15 hours Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 548.9±50.0 °C at 760 mmHg |
| Flash Point | 177.8±23.6 °C |
| Exact Mass | 430.308319 |
| PSA | 55.76000 |
| LogP | 4.22 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |