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Gamabufotalin
| Product Name | Gamabufotalin |
| Price: | $161 / 10mg |
| Catalog No.: | CN02483 |
| CAS No.: | 465-11-2 |
| Molecular Formula: | C24H34O5 |
| Molecular Weight: | 402.52 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The glandular body of Bufo bufo gargarizans Cantor. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2[C@H](O)C[C@]2([C@]1(O)CC[C@@H]2c1ccc(=O)oc1)C)C |
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| Description | Gamabufotalin (Gamabufagin), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect.IC50 value:Target: in vitro: Gamabufotalin (CS-6) strongly suppressed COX-2 expression by inhibiting the phosphorylation of IKKβ via targeting the ATP-binding site, thereby abrogating NF-κB binding and p300 recruitment to COX-2 promoter. In addition, CS-6 induced apoptosis by activating the cytochrome c and caspase-dependent apoptotic pathway [1]. Gamabufotalin significantly potentiated human breast cancer cells with different status of ER-alpha to apoptosis induction of TRAIL, as evidenced by enhanced Annexin V/FITC positive cells (apoptotic cells), cytoplasmic histone-associated-DNA-fragments, membrane permeability transition (MPT), caspases activation and PARP cleavage [2].in vivo: CS-6 markedly down-regulated the protein levels of COX-2 and phosphorylated p65 NF-κB in tumor tissues of the xenograft mice, and inhibited tumor weight and size [1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 595.8±50.0 °C at 760 mmHg |
| Flash Point | 203.4±23.6 °C |
| Exact Mass | 402.240631 |
| PSA | 90.90000 |
| LogP | 1.99 |
| Vapour Pressure | 0.0±3.8 mmHg at 25°C |
| Storage condition | -20°C |