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Germanicol
| Product Name | Germanicol |
| Price: | Inquiry |
| Catalog No.: | CN07410 |
| CAS No.: | 465-02-1 |
| Molecular Formula: | C30H50O |
| Molecular Weight: | 426.72 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The barks of Lecythis pisonis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage[1]. |
| In Vitro | Germanicol (0-100 µM；6 和 24 h) 对 HCT-116 和 HT29 人结肠癌细胞具有选择性、强效和剂量依赖性的细胞毒性，而对人结肠成纤维细胞 CCD-18Co 的细胞毒性较低。Germanicol 以剂量依赖性方式诱导 HCT-116 和 HT29 细胞死亡[1]。 Germanicol (0-100 µM；48 h) 以剂量依赖性方式诱导 HCT-116 结肠癌细胞凋亡[1]。 Germanicol (0-100 µM；0-48 h) 抑制 HCT-116 结肠癌细胞迁移[1]。 Cell Viability Assay[1] Cell Line: Human colon cancer cell lines HCT-116 (colon), HT29 (colon) and Human colon fibroblast (CCD-18Co) Concentration: 0, 5, 10, 20, 40 and 100 µM Incubation Time: 6 h and 24 h Result: Showed insignificant cytotoxicity below 20 μM and exhibited potent and dose-dependent cytotoxic effect on both HCT-116 and HT29 colon cancer cells at higher doses over 40 µM. Apoptosis Analysis[1] Cell Line: HCT-116 colon cancer cells Concentration: 0, 10, 40 and 100 µM Incubation Time: 48 h Result: Induced potent and dose-dependent chromatin condensation, accompanied by subsequent DNA damage. Cell Migration Assay [1] Cell Line: HCT-116 colon cancer cells Concentration: 0, 10, 40 and 100 µM Incubation Time: 0, 12, 24 and 48 h Result: Decreased cell migration tendency. |
| Exact Mass | 426.38600 |
| PSA | 20.23000 |
| LogP | 8.16890 |
| Vapour Pressure | 1.1E-11mmHg at 25°C |