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Dacarbazine
| Product Name | Dacarbazine |
| Price: | Inquiry |
| Catalog No.: | CN00068 |
| CAS No.: | 4342-03-4 |
| Molecular Formula: | C6H10N6O |
| Molecular Weight: | 182.19 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CN(/N=N/c1nc[nH]c1C(=O)N)C |
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| Description | Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.Target: Nucleoside antimetabolite/analogApproved: May 1975Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 456.3±55.0 °C at 760 mmHg |
| Flash Point | 229.7±31.5 °C |
| Exact Mass | 182.091614 |
| PSA | 99.73000 |
| LogP | -0.28 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | 2-8°C |