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Toddaculine
| Product Name | Toddaculine |
| Price: | $161 / 5mg |
| Catalog No.: | CN06165 |
| CAS No.: | 4335-12-0 |
| Molecular Formula: | C16H18O4 |
| Molecular Weight: | 274.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The roots of Toddalia asiatica Lam. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc2oc(=O)ccc2c(c1CC=C(C)C)OC |
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| Description | Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3]. |
| In Vitro | Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1]. |
| Density | 1.138g/cm3 |
| Boiling Point | 432.8ºC at 760 mmHg |
| Flash Point | 192.2ºC |
| Exact Mass | 274.12100 |
| PSA | 48.67000 |
| LogP | 3.31890 |
| Storage condition | 2-8℃ |