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PYR-41
| Product Name | PYR-41 |
| Price: | Inquiry |
| Catalog No.: | CN00226 |
| CAS No.: | 418805-02-4 |
| Molecular Formula: | C17H13N3O7 |
| Molecular Weight: | 371.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CCOC(=O)c1ccc(cc1)N1NC(=O)C(=Cc2ccc(o2)[N+](=O)[O-])C1=O |
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| Description | PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with no or little activity at E2. |
| Target | IC50: < 10 μM (E1) |
| In Vitro | PYR-41 increases total sumoylation in cells in addition to blocking ubiquitylation. PYR-41 attenuates cytokine-mediated nuclear factor-κB activation. PYR-41 also prevents the downstream ubiquitylation and proteasomal degradation of IκBα. Furthermore, PYR-41 inhibits degradation of p53 and activates the transcriptional activity of this tumor suppressor[1]. PYR-41 (50 μM) promotes accumulation of ubiquitinated proteins. PYR-41 causes a concentration-dependent (10-50 μM) decline in DUB activity in Z138 cells after 4 h. PYR-41 potently inhibits USP5 DUB activity, even at the lowest concentration (10 μM). PYR-41 potently (10-50 μM) inhibits the activity of various DUBs, determined to represent USP9x, USP5, USP14, UCH37 and UCH-L3. Co-treatment of Z138 cells with DTT and PYR-41 completely abolishes the accumulation of ubiquitinated proteins[2]. |
| Density | 1.5±0.1 g/cm3 |
| Exact Mass | 371.075348 |
| PSA | 134.67000 |
| LogP | 2.87 |
| Storage condition | ?20°C |