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Bruceantin
| Product Name | Bruceantin |
| Price: | Inquiry |
| Catalog No.: | CN08319 |
| CAS No.: | 41451-75-6 |
| Molecular Formula: | C28H36O11 |
| Molecular Weight: | 548.57 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The seeds of Brucea javanica. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COC(=O)[C@@]12OC[C@]34[C@H]2[C@@H](OC(=O)/C=C(/C(C)C)C)C(=O)O[C@@H]4C[C@@H]2[C@]([C@H]3[C@H]([C@@H]1O)O)(C)CC(=O)C(=C2C)O |
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| Description | Bruceantin(NSC165563) is first isolated from Brucea antidysenterica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.IC50 value:Target: anticancerCell differentiation was induced and c-MYC was down-regulated, suggesting a mechanistic correlation between c-MYC down-regulation and induction of cell differentiation or cell death. Treatment of HL-60 and RPMI 8226 cell lines induced apoptosis, and this involved the caspase and mitochondrial pathways. Moreover, an in vivo study using RPMI 8226 human-SCID xenografts demonstrated that bruceantin induced regression in early as well as advanced tumors, and these significant antitumor responses were facilitated in the absence of overt toxicity. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 731.0±60.0 °C at 760 mmHg |
| Flash Point | 239.4±26.4 °C |
| Exact Mass | 548.225769 |
| PSA | 165.89000 |
| LogP | 2.96 |
| Vapour Pressure | 0.0±5.4 mmHg at 25°C |
| Storage condition | -20°C |