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Neobavaisoflavone
| Product Name | Neobavaisoflavone |
| Price: | $74 / 20mg |
| Catalog No.: | CN05084 |
| CAS No.: | 41060-15-5 |
| Molecular Formula: | C20H18O4 |
| Molecular Weight: | 322.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The seeds of Psoralea corylifolia L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=CCc1cc(ccc1O)c1coc2c(c1=O)ccc(c2)O)C |
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| Description | Neobavaisoflavone, an isoflavone isolated from Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects. IC50 value: 42.93 μM (toward CCRF-CEM cells); 114.64 μM [against HCT116 (p53(+/+)) cells] [2]Target:In vitro: In the cancer cells, neobavaisoflavone sensitizes human U373MG glioma cells to TRAIL-mediated apoptosis; upregulated DR5 expression; induced TRAIL-mediated apoptosis in human glioma cells by suppressing migration and invasion, and by inhibiting anoikis resistance [1]. In caner cell lines, neobavaisoflavone is selectively active, and IC50 values below 115 μM were obtained on 6/9 cell lines, with values ranging from 42.93 μM (toward CCRF-CEM cells) to 114.64 μM [against HCT116 (p53(+/+)) cells] [2]. In vivo: |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 545.0±50.0 °C at 760 mmHg |
| Flash Point | 197.7±23.6 °C |
| Exact Mass | 322.120514 |
| PSA | 70.67000 |
| LogP | 4.87 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |