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Nuezhenide
| Product Name | Nuezhenide |
| Price: | $62 / 20mg |
| Catalog No.: | CN03145 |
| CAS No.: | 39011-92-2 |
| Molecular Formula: | C31H42O17 |
| Molecular Weight: | 686.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Iridoids |
| Physical Desc.: | Powder |
| Source: | The seeds of Ligustrum lucidum |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](O[C@@H]2OC=C([C@H](/C/2=CC)CC(=O)OC[C@H]2O[C@@H](OCCc3ccc(cc3)O)[C@@H]([C@H]([C@@H]2O)O)O)C(=O)OC)[C@@H]([C@H]([C@@H]1O)O)O |
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| Description | Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1]. |
| In Vitro | Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells[2]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 893.8±65.0 °C at 760 mmHg |
| Flash Point | 282.0±27.8 °C |
| Exact Mass | 686.242188 |
| PSA | 260.59000 |
| LogP | -0.31 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |