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Ophiopogonin B
| Product Name | Ophiopogonin B |
| Price: | $701 / 5mg |
| Catalog No.: | CN02533 |
| CAS No.: | 38971-41-4 |
| Molecular Formula: | C39H62O12 |
| Molecular Weight: | 722.91 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The tubers of Ophiopogon japonicus Ker-Gawler cv. Nanus |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1]. |
| Target | JNK |
| In Vitro | Ophiopogonin B (0, 5, 10and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1]. Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 835.7±65.0 °C at 760 mmHg |
| Flash Point | 459.2±34.3 °C |
| Exact Mass | 722.424133 |
| PSA | 176.76000 |
| LogP | 5.63 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |