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Jolkinolide A
| Product Name | Jolkinolide A |
| Price: | Inquiry |
| Catalog No.: | CN08552 |
| CAS No.: | 37905-07-0 |
| Molecular Formula: | C20H26O3 |
| Molecular Weight: | 314.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Cryst. |
| Source: | The herbs of Stellera chamaejasme Linn. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1]. |
| Target | VEGF[1] |
| In Vitro | Jolkinolide A (20-100 μg/mL; 24 h) 提高 A549 细胞中 caspase-9 蛋白水平[1]。 Jolkinolide A (40-80 μg/mL; 24 h) 降低 A549 细胞中 Akt-STAT3-mTOR 蛋白的表达[1]。 Jolkinolide A (20-100 μg/mL; 24 h) 抑制人脐静脉内皮细胞 (HUVEC) 增殖和迁移，促进细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: A549 cells Concentration: 20 μg/mL, 40 μg/mL, 60 μg/mL, 80 μg/mL, and 100 μg/mL Incubation Time: 24 hours Result: Promoted caspase-9 protein expression in cells at 20-100 μg/mL.Inhibited expression levels of Akt, STAT3, and mTOR proteins in cells at 40-80 μg/mL. |
| In Vivo | Jolkinolide A (40 mg/kg; 腹腔注射; 每 3 天一次，持续 2 个月) 抑制小鼠A549细胞异种移植瘤模型中VEGF蛋白的表达[1]。 Animal Model: Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; once every 3 days for 2 months Result: Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 479.5±45.0 °C at 760 mmHg |
| Flash Point | 206.7±23.3 °C |
| Exact Mass | 314.188202 |
| LogP | 4.70 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Storage condition | 2-8℃ |