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Nepodin
| Product Name | Nepodin |
| Price: | $190 / 10mg |
| Catalog No.: | CN03674 |
| CAS No.: | 3785-24-8 |
| Molecular Formula: | C13H12O3 |
| Molecular Weight: | 216.24 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The roots of Rumex nepalensis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=O)c1c(C)cc2c(c1O)c(O)ccc2 |
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| Description | Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities. |
| In Vitro | Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1]. |
| In Vivo | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2]. Animal Model: C57BL/KsJ-db/db mice[2] Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 413.2±40.0 °C at 760 mmHg |
| Flash Point | 217.8±23.8 °C |
| Exact Mass | 216.078644 |
| PSA | 57.53000 |
| LogP | 2.87 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |