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Enmein
| Product Name | Enmein |
| Price: | $290 / 10mg |
| Catalog No.: | CN08587 |
| CAS No.: | 3776-39-4 |
| Molecular Formula: | C20H26O6 |
| Molecular Weight: | 362.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Isodon japonicus |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC1OCC23C1C(C)(C)C(CC2OC(=O)C12C3CCC(C1)C(=C)C2=O)O |
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| Description | Enmein is isolated from I. serra with immunosuppressive effect[1]. |
| In Vitro | Enmein shows significant inhibitory effect toward K562 with an IC50 value ranging from 3.2 μg/ml to 8.2 μg/ml[2]. Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml[1]. Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%[1]. Cell Viability Assay[1] Cell Line: Splenic lymphocyte cells Concentration: 3.13, 6.25, 12.5, 25 μg/ml Incubation Time: 48 hours Result: Exhibited an IC50 value of 17 μg/ml in splenic lymphocytes. Cell Cycle Analysis[1] Cell Line: Splenic lymphocyte cells Concentration: 5.5 μg/ml, 11 μg/ml, 22 μg/ml Incubation Time: 48 hours Result: Caused S stage cells and G2/M stage cells decreased. |
| In Vivo | Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression[1]. Animal Model: Balb/c mice[1] Dosage: 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg Administration: Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days Result: Had inhibitory effect on IL-2 release in blood. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 610.3±55.0 °C at 760 mmHg |
| Flash Point | 220.1±25.0 °C |
| Exact Mass | 362.172943 |
| PSA | 93.06000 |
| LogP | -0.30 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |