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Kobusin
| Product Name | Kobusin |
| Price: | $439 / 5mg |
| Catalog No.: | CN02719 |
| CAS No.: | 36150-23-9 |
| Molecular Formula: | C21H22O6 |
| Molecular Weight: | 370.40 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The barks of Zanthoxylum rhetsa. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(ccc1OC)C1OCC2C1COC2c1ccc2c(c1)OCO2 |
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| Description | Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2]. |
| In Vitro | Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells[1]. |
| In Vivo | In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice[1]. |
| Exact Mass | 370.14200 |
| PSA | 55.38000 |
| LogP | 3.50770 |