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Hexahydrocurcumin
| Product Name | Hexahydrocurcumin |
| Price: | $277 / 5mg |
| Catalog No.: | CN03928 |
| CAS No.: | 36062-05-2 |
| Molecular Formula: | C21H26O6 |
| Molecular Weight: | 374.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Oil |
| Source: | The rhizomes of Curcuma longa L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(CCC(CC(=O)CCc2ccc(c(c2)OC)O)O)ccc1O |
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| Description | Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities; selective COX-2 inhibitor.IC50 value:Target: in vitro: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays [1]. HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. HHC significantly down-regulates COX-2 mRNA expression compared to the control (control: 100.05% ± 0.03% vs HHC: 61.01% ± 0.35%, P < 0.05) but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy [2].in vivo: The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression in rats [3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 622.6±55.0 °C at 760 mmHg |
| Flash Point | 218.4±25.0 °C |
| Exact Mass | 374.172943 |
| PSA | 96.22000 |
| LogP | 1.49 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Storage condition | -20°C |