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Ligustroside
| Product Name | Ligustroside |
| Price: | Inquiry |
| Catalog No.: | CN03146 |
| CAS No.: | 35897-92-8 |
| Molecular Formula: | C25H32O12 |
| Molecular Weight: | 524.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Iridoids |
| Physical Desc.: | Powder |
| Source: | The seeds of Ligustrum lucidum |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages[1][2]. |
| In Vitro | Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells[1]. |
| In Vivo | Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing[1]. Animal Model: Female NMRI mice, aged 12 months[1] Dosage: 50 mg/kg Administration: Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.) Result: Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 736.9±60.0 °C at 760 mmHg |
| Flash Point | 245.1±26.4 °C |
| Exact Mass | 524.189392 |
| PSA | 181.44000 |
| LogP | -0.31 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |