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Valerenic acid
| Product Name | Valerenic acid |
| Price: | Inquiry |
| Catalog No.: | CN09017 |
| CAS No.: | 3569-10-6 |
| Molecular Formula: | C15H22O2 |
| Molecular Weight: | 234.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Valeriana officinalis L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C[C@@H]1CC[C@H](C2=C(CC[C@H]12)C)/C=C(/C(=O)O)C |
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| Description | Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties[1][2][3]. |
| Target | 5-HT5A Receptor:17.2 μM (IC50) GABAA |
| In Vitro | Valerenic acid (1-100 μM) enhances the whole cell currents on GABAA receptors expressed in HEK 293 cells[1]. Valerenic acid exhibits significant affinity for the 5-HT5a receptor, with an IC50 of 17.2 μM (Ki=10.7 μM)[2]. [3H]Valerenic acid binds to brain membranes reveals both a high affinity binding site (KD=25 nM) and a low affinity site (KD=16 μM)[1]. [3H]Valerenic acid is displaced by Valerenol with high potency (IC50=3 nM)[1]. |
| In Vivo | Valerenic acid (1-6 mg/kg i.p. or 10 mg/kg p.o.) decreases the aversion of wild type mice to the lit area[2]. Valerenic acid (10 mg/kg; p.o.) increases the proportion of time 129X1/SvJ mice spent onto the open arms[2]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 374.5±21.0 °C at 760 mmHg |
| Flash Point | 274.2±13.0 °C |
| Exact Mass | 234.161987 |
| PSA | 37.30000 |
| LogP | 5.13 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Storage condition | −20°C |