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Caraphenol A
| Product Name | Caraphenol A |
| Price: | Inquiry |
| Catalog No.: | CN04049 |
| CAS No.: | 354553-35-8 |
| Molecular Formula: | C42H28O9 |
| Molecular Weight: | 676.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The roots of Caragana sinica |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells[1]. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively[2]. |
| Target | IFITM2, IFITM3[1] IC50: 5.9 μM (hCBS), 12.1 μM (hCSE)[2] |
| In Vitro | Caraphenol A (0-50 μM; 8 h) 增强慢病毒载体 (LV) 基因向 HeLa 的传递，但在 HEK293T 细胞中没有观察到相同作用[1]。 Caraphenol A 以依赖于内体转运的方式减少干扰素诱导的跨膜蛋白介导的限制[1]。 Caraphenol A 显著改善了低剂量和高剂量 LV 的造血干细胞 (HSC) 基因传递，而不改变 LV 整合模式[1]。 Caraphenol A (30 μM; 6 h) 促进慢病毒从核内体逃逸[1]。 Caraphenol A (30 μM; 4 h) 改变了 HeLa 细胞中 IFITM2/3 蛋白和晚期内小体的表达和亚细胞定位。Caraphenol A 对晚期核内体的影响取决于 IFITM3 的表达[1]。 |
| In Vivo | Caraphenol A (30 μM; 预处理 4 h) 处理的造血干细胞在小鼠中保持改善的基因标记，而不改变慢病毒整合谱[1]。 |
| Density | 1.5±0.1 g/cm3 |
| Exact Mass | 676.173340 |
| PSA | 152.98000 |
| LogP | 6.50 |