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Norathyriol
| Product Name | Norathyriol |
| Price: | Inquiry |
| Catalog No.: | CN05825 |
| CAS No.: | 3542-72-1 |
| Molecular Formula: | C13H8O6 |
| Molecular Weight: | 260.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Xanthones |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Mangifera indica L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities. |
| Target | PPARα:92.8 μM (IC50) PPARβ:102.4 μM (IC50) PPARγ:153.5 μM (IC50) |
| In Vitro | Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3]. Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3]Cell Growth Assay WB Cell Viability Assay[3] Cell Line: Mouse skin epidermal JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 24 or 72 hours Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death. Western Blot Analysis[3] Cell Line: JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 2 hours Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK. |
| In Vivo | Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1]. Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4]. Animal Model: Adult Kunming mice weighing 18-22 g[4] Dosage: 0.92, 1.85 and 3.7 mg/kg Administration: Administered intragastrically; twice daily for five times Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%. |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 595.1±50.0 °C at 760 mmHg |
| Flash Point | 237.8±23.6 °C |
| Exact Mass | 260.032074 |
| PSA | 111.13000 |
| LogP | 0.95 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |