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Ferrostatin-1
| Product Name | Ferrostatin-1 |
| Price: | Inquiry |
| Catalog No.: | CN00415 |
| CAS No.: | 347174-05-4 |
| Molecular Formula: | C15H22N2O2 |
| Molecular Weight: | 262.35 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CCOC(=O)c1ccc(c(c1)N)NC1CCCCC1 |
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| Description | Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM. |
| Target | EC50: 60 nM (Ferroptosis)[1] |
| In Vitro | Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS[1]. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells[2]. |
| Cell Assay | SH-S5Y cells are seeded in 24-well plates. After overnight incubation, the cells are exposed for 24 h to 1 µM of Ferrostatin-1, under standard growth conditions. Bright field photomicrographs are captured using an inverted microscope equipped with 10× objective in a live-cell modality[2]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 437.3±35.0 °C at 760 mmHg |
| Flash Point | 218.3±25.9 °C |
| Exact Mass | 262.168121 |
| PSA | 64.35000 |
| LogP | 3.90 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | 2-8°C |