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Homobutein
| Product Name | Homobutein |
| Price: | Inquiry |
| Catalog No.: | CN05608 |
| CAS No.: | 34000-39-0 |
| Molecular Formula: | C16H14O5 |
| Molecular Weight: | 286.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Powder |
| Source: | The flower heads of Dahlia tenuicaulis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4]. |
| In Vitro | Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1]. Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1]. Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2]. Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 µM, respectively[3]. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 20, 24, 28, 32, 40 μM Incubation Time: 2 h Result: Showed inhibition of viability in K562 cells. Cell Viability Assay[2] Cell Line: Toxoplasma gondii RH-2F strain Concentration: 1 μg/mL Incubation Time: 72 h Result: Surpressed 19.48% of the Toxoplasma gondii. |
| Density | 1.369 g/cm3 |
| Boiling Point | 523.8ºC at 760 mmHg |
| Flash Point | 197.6ºC |
| Exact Mass | 286.08400 |
| PSA | 86.99000 |
| LogP | 2.70810 |