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Mdivi-1
| Product Name | Mdivi-1 |
| Price: | Inquiry |
| Catalog No.: | CN00240 |
| CAS No.: | 338967-87-6 |
| Molecular Formula: | C15H10Cl2N2O2S |
| Molecular Weight: | 353.22 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(c(cc1Cl)Cl)n1c(S)nc2c(c1=O)cccc2 |
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| Description | Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. |
| In Vitro | Mdivi-1 inhibits Dnm1 GTPase activity in a dose-dependent manner, with an estimated EC50 of 1-10 μM. Mdivi-1 increases the apparent K0.5 for GTP, lowers the apparent Vmax for GTP hydrolysis, and causes an increase in the Hill coefficient observed for GTP in the Dnm1 GTP hydrolysis reaction[1]. Cells treated with mdivi-1 display decreased cytochrome c release and a reduced rate of phosphatidylserine exposure on their surface following apoptosis induction, consistent with an inhibition of apoptosis and with previous studies using other strategies to compromise DRP1 activity[2]. Mdivi-1 results in apoptotic cell death in ischemic retina[3]. |
| In Vivo | The mitochondrial division DRP, Dnm1, is the target of mdivi-1 in vivo. Mdivi-1 quantitatively blocks GMPPCP- dependent Dnm1 self-assembly in a concentration range similar to its effects on mitochondrial division in vivo[1]. Mdivi-1 (50 mg/kg, i.p.) significantly decreases GFAP protein expression in the normal mouse retina[3]. |
| Cell Assay | YPGlycerol plates are topped with 10 mL YPGlycerol containing 1% low melt agar and 75 μM mdivi-1, and cells are spotted 12 hours later using a 48 well pinning device. After pinning cells, plates are incubated at 24°C or 37°C and imaged using an Eagle Eye II imaging system. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 522.5±60.0 °C at 760 mmHg |
| Flash Point | 269.8±32.9 °C |
| Exact Mass | 351.984009 |
| PSA | 82.92000 |
| LogP | 3.85 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Storage condition | Store at -20°C |