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8-Epixanthatin
| Product Name | 8-Epixanthatin |
| Price: | Inquiry |
| Catalog No.: | CN09083 |
| CAS No.: | 30890-35-8 |
| Molecular Formula: | C15H18O3 |
| Molecular Weight: | 246.30 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The root exudates of sunflower. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | 8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity[1]. |
| In Vitro | 8-Epixanthatin(2-20 μM, 12 h) 可以以剂量依赖性方式抑制 DU145 细胞增殖和 DU145 细胞的 p-STAT3 水平，其 IC50 值为 3.2 μM[1]。 8-Epixanthatin可以通过诱导 DU145 癌细胞中 ROS 的产生抑制 STAT3 的激活和细胞增殖[1]。 Cell Proliferation Assay[1] Cell Line: DU145 cell Concentration: 2, 5, 10, and 20 μM Incubation Time: 12 h or 48 h Result: Reduced STAT3 phosphorylation by 90% at a concentration of 20 μM but not p-JAK2-Y1007/1008. Significantly reduced the amount of BCL-2 and BCL-xL, and induces BCL-xL PARP cleavage, the percentage of cells in G0/G1 phase decreased. |
| In Vivo | 8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低[1]。 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 444.3±45.0 °C at 760 mmHg |
| Flash Point | 199.1±28.8 °C |
| Exact Mass | 246.125595 |
| LogP | 1.58 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | 2-8℃ |