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Geldanamycin
| Product Name | Geldanamycin |
| Price: | Inquiry |
| Catalog No.: | CN00246 |
| CAS No.: | 30562-34-6 |
| Molecular Formula: | C29H40N2O9 |
| Molecular Weight: | 560.64 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(C2=O)NC(=O)C(=CC=C[C@@H]([C@H](C(=C[C@@H]([C@H]1O)C)C)OC(=O)N)OC)C |
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| Description | Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. |
| Target | HSP90:1.2 μM (Kd) |
| In Vitro | Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells[1]. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment[2]. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism[3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 783.9±60.0 °C at 760 mmHg |
| Flash Point | 427.9±32.9 °C |
| Exact Mass | 560.273376 |
| PSA | 163.48000 |
| LogP | 2.00 |
| Vapour Pressure | 0.0±6.2 mmHg at 25°C |
| Storage condition | −20°C |