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Gossypol
| Product Name | Gossypol |
| Price: | $46 / 20mg |
| Catalog No.: | CN03781 |
| CAS No.: | 303-45-7 |
| Molecular Formula: | C30H30O8 |
| Molecular Weight: | 518.56 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Gossypium spp. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | O=Cc1c(O)c(O)c(c2c1c(O)c(c(c2)C)c1c(C)cc2c(c1O)c(C=O)c(c(c2C(C)C)O)O)C(C)C |
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| Description | Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively. |
| Target | Bcl-xL:0.5-0.6 μM (Ki) Bcl-2:0.2-0.3 mM (Ki) |
| In Vitro | Gossypol, a natural product isolated from cottonseeds and roots that has been studied as an anticancer agent. The racemic form of Gossypol [(±)-Gossypol] is tested in several clinical trials and is well tolerated. The racemic form Gossypol ((±)-Gossypol) binds to Bcl-xL protein with a Ki of 0.5 to 0.6 μM. (±)-Gossypol also potently binds to Bcl-2 protein with a Ki value of 0.2-0.3 mM. The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (+)-Gossypol enantiomers. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001)[1]. |
| Cell Assay | Two representative UM-SCC cell lines, UM-SCC-6 and UM-SCC-14A, are continuously exposed to 0 (vehicle control), 5 or 10 μM (±)-Gossypol, (-)-Gossypol or (+)-Gossypol in a 6-day MTT cell survival assay[1]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 707.9±55.0 °C at 760 mmHg |
| Flash Point | 395.9±28.0 °C |
| Exact Mass | 518.194092 |
| PSA | 155.52000 |
| LogP | 6.16 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |