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Lasiocarpine
| Product Name | Lasiocarpine |
| Price: | Inquiry |
| Catalog No.: | CN01608 |
| CAS No.: | 303-34-4 |
| Molecular Formula: | C21H33NO7 |
| Molecular Weight: | 411.49 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Heliotropium indicum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1]. |
| In Vitro | Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine[1]. Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors[1]. Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 519.8±50.0 °C at 760 mmHg |
| Flash Point | 268.1±30.1 °C |
| Exact Mass | 411.225708 |
| PSA | 105.53000 |
| LogP | 2.85 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |