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Diphyllin O-glucoside
| Product Name | Diphyllin O-glucoside |
| Price: | Inquiry |
| Catalog No.: | CN02693 |
| CAS No.: | 30021-77-3 |
| Molecular Formula: | C27H26O12 |
| Molecular Weight: | 542.49 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The herbs of Sinopodophyllum hexandrum |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4]. |
| Target | IC50: 6.51 µM (SARS-CoV-2)[1] |
| In Vitro | Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1]. Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1]. |
| In Vivo | Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2]. |
| Exact Mass | 542.14200 |
| PSA | 162.60000 |
| LogP | 1.10180 |
| Storage condition | 2-8°C |