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Malvidin-3-O-arabinoside chloride
| Product Name | Malvidin-3-O-arabinoside chloride |
| Price: | Inquiry |
| Catalog No.: | CN05121 |
| CAS No.: | 28500-04-1 |
| Molecular Formula: | C22H23ClO11 |
| Molecular Weight: | 498.9 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The fruits of Vaccinium myrtillus |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1]. |
| In Vitro | Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1]. Cell Autophagy Assay[1] Cell Line: Caco-2 cell line. Concentration: 50, 100, 200 and 400 μM. Incubation Time: 24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h). Result: Notably inhibited excess ROS generation. 200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level. Enhanced autophagy flux. Significantly up-regulate the LC3-II/LC3-I ratio. |
| Exact Mass | 498.092896 |