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Isosteviol
| Product Name | Isosteviol |
| Price: | $31 / 20mg |
| Catalog No.: | CN08585 |
| CAS No.: | 27975-19-5 |
| Molecular Formula: | C20H30O3 |
| Molecular Weight: | 318.45 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Stevia rebaudiana |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)[C@@]1(C)CCC[C@]2([C@H]1CC[C@]13[C@@H]2CC[C@@](C3)(C(=O)C1)C)C |
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| Description | Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, which is commonly used as a noncaloric sugar substitute in Japan and Brazil.Target:Isosteviol dose-dependently relaxed the vasopressin (10-8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10-2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10-8 M vasopressin [1]. The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca (2+)]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca (2+)]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present [2]. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II [3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 455.6±38.0 °C at 760 mmHg |
| Flash Point | 243.5±23.3 °C |
| Exact Mass | 318.219482 |
| PSA | 54.37000 |
| LogP | 4.13 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Storage condition | -20°C |