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Thiocolchicine
| Product Name | Thiocolchicine |
| Price: | Inquiry |
| Catalog No.: | CN00029 |
| CAS No.: | 2730-71-4 |
| Molecular Formula: | C22H25NO5S |
| Molecular Weight: | 415.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The bulbs of Colchicum autumnale L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. |
| In Vitro | Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively[3]. Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. It inhibits cell proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells with IC50s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells (IC50=50 nM)[2]. |
| Density | 1.27g/cm3 |
| Boiling Point | 729.1ºC at 760mmHg |
| Flash Point | 394.7ºC |
| Exact Mass | 415.14500 |
| PSA | 99.16000 |
| LogP | 3.97580 |
| Vapour Pressure | 4.12E-21mmHg at 25°C |