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Perivine
| Product Name | Perivine |
| Price: | Inquiry |
| Catalog No.: | CN01296 |
| CAS No.: | 2673-40-7 |
| Molecular Formula: | C20H22N2O3 |
| Molecular Weight: | 338.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Catharanthus roseus G. Don |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease[1]. |
| Target | IC50: Retinoblastoma-associated proteins (RbAp48)[1] |
| In Vitro | Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy[1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 541.1±50.0 °C at 760 mmHg |
| Flash Point | 281.0±30.1 °C |
| Exact Mass | 338.163055 |
| PSA | 71.19000 |
| LogP | 3.53 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |