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PR-619
| Product Name | PR-619 |
| Price: | Inquiry |
| Catalog No.: | CN00249 |
| CAS No.: | 2645-32-1 |
| Molecular Formula: | C7H5N5S2 |
| Molecular Weight: | 223.28 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | N#CSc1cc(SC#N)c(nc1N)N |
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| Description | PR-619 is a broad-range DUB inhibitor with EC50 of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively. |
| Target | EC50: 3.93 μM (USP4), 4.9 μM (USP8), 6.86 μM (USP7), 7.2 μM (USP2), 8.61 μM (USP5)[1] |
| In Vitro | PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation. In PR-619 treated cells, channel degradation is significantly inhibited with 87±1% of KCa3.1 still remaining after 24 hrs (n=3; P<0.05)[2]. Cell viability is determined by MTT assay and revealed that PR-619 exerted concentration-dependent cytotoxicity in a very narrow concentration range of 7-10 μM[3]. |
| Cell Assay | Growth inhibition is determined with the exception that HCT-116 or HEK293T cells maintained in DMEM supplemented with 10% (v/v) FBS, 1% (v/v) penicillin/streptomycin and 2 mM L-glutamine are exposed to dose ranges of PR-619 (1, 5, 10, 20, and 50 μM) or P22077 for 72 hours[1]. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 406.0±45.0 °C at 760 mmHg |
| Flash Point | 199.3±28.7 °C |
| Exact Mass | 222.998642 |
| PSA | 163.84000 |
| LogP | 2.05 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Storage condition | ?20°C |