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Furanodienone
| Product Name | Furanodienone |
| Price: | $204 / 10mg |
| Catalog No.: | CN09341 |
| CAS No.: | 24268-41-5 |
| Molecular Formula: | C15H18O2 |
| Molecular Weight: | 230.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Curcuma zedoaria. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C/C/1=C/C(=O)c2c(C/C(=CCC1)/C)occ2C |
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| Description | Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1]. |
| In Vitro | Furanodienone (0-573.8 μM; 24 hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1]. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1]. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1]. Western Blot Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 50 μM; 100 μM; 150 μM Incubation Time: 24 hours Result: Increased caspase-9 and -3. Apoptosis Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 75 μM; 150 μM Incubation Time: 24 hours Result: Induced apoptosis of colorectal cells (RKO and HT-29). |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 363.8±42.0 °C at 760 mmHg |
| Flash Point | 172.0±20.6 °C |
| Exact Mass | 230.130676 |
| PSA | 30.21000 |
| LogP | 4.76 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Storage condition | 2-8℃ |