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Trametenolic acid
| Product Name | Trametenolic acid |
| Price: | Inquiry |
| Catalog No.: | CN07665 |
| CAS No.: | 24160-36-9 |
| Molecular Formula: | C30H48O3 |
| Molecular Weight: | 456.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The sclerotium of Poria cocos(Schw.)Wolf |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Trametenolic acid is a lanostanol glycoside that isolated from the EtOH extract of the fruit bodies of Laetiporus versisporus[1]. |
| Target | ERK1 ERK2 |
| In Vitro | Trametenolic acid (1 mg/mL; 15-30 mins) induces the upregulation of autophagy-related proteins (Beclin-1, Atg12, and LC3) in B16-F1 cells by activating the ERK1/2 signaling pathway[1]. Trametenolic acid (1 mg/mL; 24 hours; B16-F1 cells) has dual synergic mechanisms to exert an anti-melanogenetic effect[1]. Trametenolic acid (0.1-4 mg/mL; 52 hours; B16-F1 cells) increase melanin synthesis by approximately 20% and 40% in cells transfected with siRNAs against mTOR and Atg5, respectively[1]. Western Blot Analysis[1] Cell Line: B16-F1 cells Concentration: 1 mg/mL Incubation Time: 15 and 30 mins Result: Increased the expression levels of phospho-p38, phospho-ERK1/2, Beclin-1, Atg12 and LC3 by approximately 46%, 10%, 48%, 126% and 49%, respectively. Western Blot Analysis[1] Cell Line: B16-F1 cells Concentration: 1 mg/mL Incubation Time: 24 hours Result: Increased the expression of ERK1/2 and p-ERK1/2 and decreased MITF, tyrosinase, and TRP 1 levels. |
| Density | 1.07±0.1 g/cm3 |
| Exact Mass | 456.36000 |
| PSA | 57.53000 |
| LogP | 7.54380 |
| Vapour Pressure | 3.26E-15mmHg at 25°C |
| Storage condition | 2-8℃ |