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Pratensein
| Product Name | Pratensein |
| Price: | $556 / 5mg |
| Catalog No.: | CN04821 |
| CAS No.: | 2284-31-3 |
| Molecular Formula: | C16H12O6 |
| Molecular Weight: | 300.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Trifolium pratense L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc(cc1O)c1coc2c(c1=O)c(O)cc(c2)O |
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| Description | Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1]. |
| In Vivo | Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1]. Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1]. Animal Model: Male 10-week old Wistar rats[1] Dosage: 20 mg/kg Administration: P.o.; once daily for 3 weeks Result: The spatial learning and memory ability of rats was improved. |
| Density | 1.512g/cm3 |
| Boiling Point | 576.7ºC at 760mmHg |
| Flash Point | 220.3ºC |
| Exact Mass | 300.06300 |
| PSA | 100.13000 |
| LogP | 2.58540 |
| Vapour Pressure | 6.73E-14mmHg at 25°C |