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Isocryptotanshinone
| Product Name | Isocryptotanshinone |
| Price: | Inquiry |
| Catalog No.: | CN08689 |
| CAS No.: | 22550-15-8 |
| Molecular Formula: | C19H20O3 |
| Molecular Weight: | 296.36 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Salvia miltiorrhiza |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B. |
| Target | STAT3 PTP1B:56.1 μM (IC50) |
| In Vitro | It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1]. |
| Exact Mass | 296.14100 |
| PSA | 43.37000 |
| LogP | 3.59990 |