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Podocarpusflavone A
| Product Name | Podocarpusflavone A |
| Price: | Inquiry |
| Catalog No.: | CN05446 |
| CAS No.: | 22136-74-9 |
| Molecular Formula: | C31H20O10 |
| Molecular Weight: | 552.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The barks of Podocarpus macrophyllus |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc(cc1)c1cc(=O)c2c(o1)c(c(cc2O)O)c1cc(ccc1O)c1cc(=O)c2c(o1)cc(cc2O)O |
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| Description | Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugstarget: DNA topoisomerase IIn vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase than the control group. |
| Target | Topoisomerase I:119.425 μM (IC50) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 879.3±65.0 °C at 760 mmHg |
| Flash Point | 295.2±27.8 °C |
| Exact Mass | 552.105652 |
| PSA | 170.80000 |
| LogP | 4.15 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Storage condition | 2-8℃ |