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Diphyllin
| Product Name | Diphyllin |
| Price: | $511 / 10mg |
| Catalog No.: | CN02692 |
| CAS No.: | 22055-22-7 |
| Molecular Formula: | C21H16O7 |
| Molecular Weight: | 380.35 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The herbs of Sinopodophyllum hexandrum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc2c(c3ccc4c(c3)OCO4)c3C(=O)OCc3c(c2cc1OC)O |
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| Description | Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3]. |
| Target | HIV-1:0.38 μM (IC50) Vesicular stomatitis virus (VSV) Vacuolar type H+-ATPase:17 nM (IC50) |
| Density | 1.445g/cm3 |
| Boiling Point | 638.8ºC at 760 mmHg |
| Flash Point | 232.4ºC |
| Exact Mass | 380.09000 |
| PSA | 83.45000 |
| LogP | 3.62870 |
| Vapour Pressure | 6.53E-17mmHg at 25°C |
| Storage condition | 2-8℃ |