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Bruceine D
| Product Name | Bruceine D |
| Price: | Inquiry |
| Catalog No.: | CN08501 |
| CAS No.: | 21499-66-1 |
| Molecular Formula: | C20H26O9 |
| Molecular Weight: | 410.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The barks of Ailanthus altissima |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC1=CC(=O)[C@H]([C@]2([C@H]1C[C@H]1OC(=O)[C@@H]([C@@]3([C@]41C2[C@@H](O)[C@@H]([C@]3(OC4)C)O)O)O)C)O |
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| Description | Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. |
| Target | Notch[1] |
| In Vitro | Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1]. Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1]. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 661.3±55.0 °C at 760 mmHg |
| Flash Point | 235.8±25.0 °C |
| Exact Mass | 410.157684 |
| PSA | 153.75000 |
| LogP | -0.50 |
| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
| Storage condition | 2-8C |