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Gardenin A
| Product Name | Gardenin A |
| Price: | Inquiry |
| Catalog No.: | CN04314 |
| CAS No.: | 21187-73-5 |
| Molecular Formula: | C21H22O9 |
| Molecular Weight: | 418.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The fruits of Gardenia jasminoides Ellis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects[1][2]. |
| In Vitro | Gardenin A (10-20 μM; 48 h) 可诱导 PC12 细胞神经突生长，(10 μM; 24 小时和 48 小时) 还增加神经元分化和突触形成标记蛋白、生长相关蛋白-43 (GAP-43) 和突触素的表达[1]。 Gardenin A (10 μM; 30-120分钟) 显著诱导环 AMP 反应元件结合蛋白(CREB) 的磷酸化和 CRE 介导的转录，这是通过抑制剂 2-萘酚AS-E 磷酸盐 (KG-501) 或使用 CREB siRNA 来抑制的[1]。 Gardenin A (10 μM; 15-120分钟) 增加 ERK 磷酸化水平，提高 PKA 和 PKC 活性[1]。 Cell Viability Assay[1] Cell Line: PC12 cells Concentration: 2, 5, 10, 20 μM Incubation Time: 48 hours Result: showed cell growth supporting effect at higher concentrations (10-20 µM) and did not exert detectable 237 cytotoxicity on PC12 cells after 48 h incubation in low serum medium. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 10 μM Incubation Time: 0, 15, 30, 60, and 120 min Result: Significantly increased the phosphorylation of ERK1/2 (Thr202/Tyr204) at 15 min, subsequently reduced after 30 min. Increased PKC and PKA activity peaked at 15 min.Increased CREB phosphorylation. |
| In Vivo | Gardenin A (0.1-25 mg/kg; 口服; 单剂量) 具有神经药理作用，包括镇静、抗焦虑、抗抑郁和抗惊厥作用的小鼠[2]。 栀子苷A (1-10 mg/kg; 口服; 单次剂量) 不影响小鼠的运动协调和延迟惊厥的发生[2]。 Animal Model: Male Balb/c mice (24-32 g)[2] Dosage: 1 mg/kg, 10 mg/kg, 25 mg/kg Administration: Oral gavage; single dose Result: Showed sedative effects at a dose of 25 mg/kg, which increased the duration of sleep but did not alter sleep onset. |
| Density | 1.3g/cm3 |
| Boiling Point | 624.2ºC at 760 mmHg |
| Flash Point | 218.5ºC |
| Exact Mass | 418.12600 |
| PSA | 105.82000 |
| LogP | 3.21720 |
| Vapour Pressure | 3.57E-16mmHg at 25°C |
| Storage condition | -20°C |