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Mahanimbine
| Product Name | Mahanimbine |
| Price: | Inquiry |
| Catalog No.: | CN01263 |
| CAS No.: | 21104-28-9 |
| Molecular Formula: | C23H25NO |
| Molecular Weight: | 331.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Murraya exotica |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=CCC[C@@]1(C)C=Cc2c(O1)c(C)cc1c2[nH]c2c1cccc2)C |
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| Description | Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1]. |
| In Vivo | Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1]. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1]. Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1]. Animal Model: Swiss albino mice (7-8 weeks old, both sex)[1] Dosage: HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine); Administration: Oral suspension; daily for 12 weeks Result: Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain. |
| Density | 1.109g/cm3 |
| Boiling Point | 502.6ºC at 760 mmHg |
| Flash Point | 178.3℃ |
| Exact Mass | 331.19400 |
| PSA | 25.02000 |
| LogP | 6.54020 |
| Vapour Pressure | 9.76E-10mmHg at 25°C |
| Storage condition | 2-8℃ |