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Dihydroisotanshinone I
| Product Name | Dihydroisotanshinone I |
| Price: | Inquiry |
| Catalog No.: | CN08740 |
| CAS No.: | 20958-18-3 |
| Molecular Formula: | C18H14O3 |
| Molecular Weight: | 278.30 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Red powder |
| Source: | The roots of Salvia miltiorrhiza Bge. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen. |
| Target | STAT3 |
| In Vitro | Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1[1]. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently[2]. |
| Cell Assay | Dihydroisotanshinone I is dissolved in ethyl acetate and mixed with the culture medium. The final concentration of ethyl acetate is 0.1% (v/v). Cell are treated with 2.5, 5, 10, and 20 μM dihydroisotanshinone I for 24 hours. The cell viability is measured using the MTT assay[2]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 479.2±45.0 °C at 760 mmHg |
| Flash Point | 214.9±28.8 °C |
| Exact Mass | 278.094299 |
| PSA | 43.37000 |
| LogP | 3.90 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |