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alpha-Chaconine
| Product Name | alpha-Chaconine |
| Price: | Inquiry |
| Catalog No.: | CN01171 |
| CAS No.: | 20562-03-2 |
| Molecular Formula: | C45H73NO14 |
| Molecular Weight: | 852.06 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The peels of Solanum tuberosum |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | α-Chaconine, isolated from a Solanum tuberosum L. cv Jayoung, inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects[1]. |
| Target | COX-2 |
| In Vitro | α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling[1]. |
| Density | 1.37 g/cm3 |
| Exact Mass | 851.50300 |
| PSA | 220.46000 |
| LogP | 1.12070 |