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Isodiospyrin
| Product Name | Isodiospyrin |
| Price: | Inquiry |
| Catalog No.: | CN05911 |
| CAS No.: | 20175-84-2 |
| Molecular Formula: | C22H14O6 |
| Molecular Weight: | 374.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Quinones |
| Physical Desc.: | Red powder |
| Source: | The herbs of Diospyros morrisiana |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3]. |
| Target | Topoisomerase I |
| In Vitro | Isodiospyrin (10-40 μM) 不诱导人拓扑异构酶 I (htopo I)-DNA 共价复合物。然而，Isodiospyrin 拮抗 Camptothecin 诱导的 htopo I 介导的 DNA 裂解。Isodiospyrin 结合 htopo I 但不结合 DNA。在 DNA 不存在的情况下，Isodiospyrin 对 htopo I 对剪接因子 2/替代剪接因子的激酶活性具有强烈的抑制作用[1]。 Isodiospyrin 针对革兰氏阳性菌的 MIC 范围为 0.78 至 50 μg/mL。 Isodiospyrin 针对铜绿假单胞菌 ATCC 15443 和伤寒沙门氏菌的浓度范围为 50 至 100 μg/mL。对 M. chelonae 的 MIC 在 6.25 和 25 μg/mL 之间[2]。 Isodiospyrin（30 μM；120-144 小时）显示出 81.4 % 的 P. obscurans 生长抑制。30 μM Isodiospyrin 对 P. viticola 的抗真菌活性为 57.7 %[3]。 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 712.0±60.0 °C at 760 mmHg |
| Flash Point | 398.3±29.4 °C |
| Exact Mass | 374.079041 |
| PSA | 108.74000 |
| LogP | 3.83 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |